This line passed through mostly rural areas of southern Pennsylvania. It was a branch off of the Hagerstown, MD to Harrisburg, PA line. It survived into the Penn Central years (mid-1970s) but was abandoned before the startup of Conrail in 1976. In Fayetteville, US 30 crossed over the line with a single concrete arch bridge. Some walking paths have been created in the Fayetteville area, south of US 30, but they do not follow the former right-of-way. The paths also use a former railroad girder bridge in the area, but that bridge is also not in its original location. PA Route 997 parallels the former line for about three miles, between Mont Alto and Nunnery. The south end of the branch connected with the (also abandoned) Western Maryland at the north edge of Waynesboro; see Quinsonia, PA to Edgemont, MD.

Heading south from Waynesboro Junction, this PRR branch passed through Burgner, Woodstock, Fayetteville, East Fayetteville, Pond Bank, Mont Alto, Good (Knepper), Quincy, and Nunnery, and then ended at the WM Junction at Waynesboro. There was a spur to Mont Alto Park in Mont Alto.

The right-of-way is mostly on private property, and is not developed as a trail, although short segments are used as parts of driveways.