This line passed through mostly rural areas of southern Pennsylvania and northern Maryland, though there was some industry in Waynesboro. The connecting lines at the junctions at both ends of this abandoned segment are active CSX lines.

Branching from the former Western Maryland, now CSX, Hagerstown-Shippensburg line in Quinsonia (nee-Conboy), this route passed through Elbrook, Five Forks, Waynesboro, Cress and Midvale, PA, and on to Edgemont, MD, where it joined another former WM mainline. The line north of Waynesboro was in place until the 1980s. The southern segment, to Edgemont, MD, was abandoned in 1960.

The right of way is mostly on private property.

See also the The Waynesboro Branch in PA.