This line was formerly part of the B&O main line from Washington to St. Louis. This section and most of the line from Clarksburg to Cincinnati was abandoned in 1985, with rails being removed on this section in 1989.
Towns on this line from Parkersburg east are Nicholette, Davisville, Kanawha, Walker, Eaton, Petroleum (Volcano Jct), Silver Run, Cairo, Cornwallis, Ellenboro, Lamberton, Pennsboro, Toll Gate, Greenwood, Duckworth, Central, West Union, Smithburg, Castlebrook Siding, Morganville, Long Run, Industrial School, Salem, Bristol, Maken, Wolf Summit, Reynoldsville, Wilsonburg and into Clarksburg at Short Line Jct.