This abandoned railway passed through mostly farming areas of Delaware and Maryland's eastern shore. It was a branch off of the Pennsylvania RR's Delmarva peninsula line. It survived the Penn Central years but was later sold off as part of the Maryland & Delaware (MDDE) instead of becoming part of Conrail. The Clayton, DE to Easton, MD segment was in turn spun off by the MDDE to the Chesapeake RR (CHRR).
Heading southwest from Clayton, DE, the line passed through Kenton, Hartly, and Slaughter, DE and then through Marydel, Henderson, Goldsboro, Greensboro, Ridgely, Hillsboro, Queen Anne, Cordova, Chapel, and Easton, MD. At some point the line extended beyond Easton through Landaff and Trappe to Oxford on the eastern shore of Chesapeake Bay.
Though this line is out of service, it is listed on the official Maryland state map as "MDOT" (Maryland Department of Transportation) as the line is 'rail-banked' for possible future use.
Thanks to Jay Davis for contributing information about this route.